Shivashankar Othy

The overarching goal of my research is to uncover the principles of immune regulation at the organismal, cellular, and molecular levels. My lab is investigating 1) Mechanisms of regulatory T cells to harness their therapeutic potential for autoimmune encephalomyelitis; 2) Role of mechanosensitive Piezo1 channels in tumor immunity and myelin repair; 3) Immunobiology of adjuvants for safe and effective vaccines. In the long term, I seek to broaden our understanding of how immune cells play essential roles in human health and disease and develop new therapeutic strategies for infectious diseases, autoimmune disorders, organ transplantation, and solid tumors.