The human genome contains less than 25,000 genes. However, the vast majority of our genes can produce multiple RNAs that encode different proteins and/or harbor different regulatory sequences. This is achieved largely by alternative mRNA splicing and polyadenylation. When, where, and how much is a specific RNA expressed?  How are these processes regulated? How does the mis-regulation of these processes contribute to human diseases? Our lab is devoted to answering these questions. We combine biochemical, structural, and high throughput sequencing-based global analyses in our research.

Current projects in the lab include:

• Characterization of the mRNA 3′ processing machinery.
• Alternative splicing and polyadenylation  in cell fate decisions.
• mRNA 3′ processing and host-pathogen interactions.
• mRNA 3′ processing in adaptive immunity.