We study the intricate role of the kidney, a vital organ responsible for eliminating waste products from the blood while ensuring the reabsorption of essential nutrients. Our research primarily revolves around malignant tumor formation in the kidneys, as it not only disrupts kidney function but also has far-reaching consequences on the entire body.

Our particular area of interest lies in studying a genetic kidney tumor syndrome known as Tuberous Sclerosis Complex (TSC). This syndrome arises from loss-of-function mutations in the TSC1/2 tumor suppressor genes. By utilizing TSC mouse models and analyzing patient samples, we aim to identify the signaling and metabolic perturbations involved in kidney tumor pathogenesis. Through our research endeavors, we aspire to contribute to the development of effective treatments and diagnostic tools that can improve patient outcomes.