Our research is focused on the processes of blood vessel development and angiogenesis and how these relate to normal wound healing and tumor growth. In particular, we wish to identify the genes that regulate the specific phenotypes adopted by angiogenic endothelial cells (EC), such as tip cells, tube-forming cells, and anastomosing cells, as these may provide unique drug targets for anti-angiogenic therapy. We have developed several in vitro and in vivo tools that model different aspects of these processes.